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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 2
2004 2
2006 1
2011 2
2012 2
2013 3
2014 4
2015 1
2016 2
2017 1
2018 5
2019 1
2020 2
2021 5
2022 1
2023 3
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35 results

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Page 1
Potential Roles of Dec and Bmal1 Genes in Interconnecting Circadian Clock and Energy Metabolism.
Sato F, Kohsaka A, Bhawal UK, Muragaki Y. Sato F, et al. Int J Mol Sci. 2018 Mar 8;19(3):781. doi: 10.3390/ijms19030781. Int J Mol Sci. 2018. PMID: 29518061 Free PMC article. Review.
The clock genes have been revealed not only to form the molecular clock but also to function as a mediator that regulates both circadian and metabolic functions. ...Among the clock genes, Dec1 (Bhlhe40/Stra13/Sharp2), Dec2 (Bhlhe41/Sharp1), and Bmal1 ( …
The clock genes have been revealed not only to form the molecular clock but also to function as a mediator that regulates both …
A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans.
Pellegrino R, Kavakli IH, Goel N, Cardinale CJ, Dinges DF, Kuna ST, Maislin G, Van Dongen HP, Tufik S, Hogenesch JB, Hakonarson H, Pack AI. Pellegrino R, et al. Sleep. 2014 Aug 1;37(8):1327-36. doi: 10.5665/sleep.3924. Sleep. 2014. PMID: 25083013 Free PMC article.
Both twins had almost identical amounts of non rapid eye movement (NREM) sleep. This variant reduced the ability of BHLHE41 to suppress CLOCK/BMAL1 and NPAS2/BMAL1 transactivation in vitro. ...Mutations that affect sleep also modify the normal inhibition of BHLHE …
Both twins had almost identical amounts of non rapid eye movement (NREM) sleep. This variant reduced the ability of BHLHE41 to suppre …
Lithium response in bipolar disorders and core clock genes expression.
Geoffroy PA, Curis E, Courtin C, Moreira J, Morvillers T, Etain B, Laplanche JL, Bellivier F, Marie-Claire C. Geoffroy PA, et al. World J Biol Psychiatry. 2018 Dec;19(8):619-632. doi: 10.1080/15622975.2017.1282174. Epub 2017 Feb 28. World J Biol Psychiatry. 2018. PMID: 28095742
OBJECTIVES: We examine whether the lithium response is associated with changes in the expression of core clock genes. METHODS: The effect of a therapeutic concentration of lithium (1 mM) on the expression levels of 17 circadian genes was examined in lymphoblastoid cell lin …
OBJECTIVES: We examine whether the lithium response is associated with changes in the expression of core clock genes. METHODS: The ef …
DEC1 and DEC2 Crosstalk between Circadian Rhythm and Tumor Progression.
Sato F, Bhawal UK, Yoshimura T, Muragaki Y. Sato F, et al. J Cancer. 2016 Jan 1;7(2):153-9. doi: 10.7150/jca.13748. eCollection 2016. J Cancer. 2016. PMID: 26819638 Free PMC article. Review.
Clock genes, major regulators of circadian rhythm, are involved in tumor progression. We have shown that clock genes basic helix-loop-helix (BHLH) transcription factors, differentiated embryonic chondrocyte gene 1 (DEC1/BHLHE40/Sharp2/Stra13) and DEC2 (BHLHE41 …
Clock genes, major regulators of circadian rhythm, are involved in tumor progression. We have shown that clock genes basic hel …
The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation.
Wang X, Sato F, Tanimoto K, Rajeshwaran N, Thangavelu L, Makishima M, Bhawal UK. Wang X, et al. Int J Mol Sci. 2021 Sep 26;22(19):10349. doi: 10.3390/ijms221910349. Int J Mol Sci. 2021. PMID: 34638690 Free PMC article. Review.
In recent years, studies of differentiated embryo-chondrocyte expressed genes 1 and 2 (Dec1 and Dec2) have shown that they play important functions in autophagy and in pyroptosis, which contribute to the onset of periodontal inflammation. In this review, we summarize recent studi …
In recent years, studies of differentiated embryo-chondrocyte expressed genes 1 and 2 (Dec1 and Dec2) have shown that they play important fu …
The Paralogous Kruppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.
Knoedler JR, Ávila-Mendoza J, Subramani A, Denver RJ. Knoedler JR, et al. J Biol Rhythms. 2020 Jun;35(3):257-274. doi: 10.1177/0748730420913205. Epub 2020 Apr 3. J Biol Rhythms. 2020. PMID: 32241200 Free PMC article.
Here, we report that the zinc finger transcription factor Kruppel-like factor 9 (KLF9) is regulated by this TTFL, it associates in chromatin at the core circadian clock and clock-output genes, and it acts to modulate transcription of the clock-output gene Dbp …
Here, we report that the zinc finger transcription factor Kruppel-like factor 9 (KLF9) is regulated by this TTFL, it associates in chromatin …
Disruptions of Circadian Genes in Cutaneous Melanoma-An In Silico Analysis of Transcriptome Databases.
Lesicka M, Nedoszytko B, Reszka E. Lesicka M, et al. Int J Mol Sci. 2023 Jun 14;24(12):10140. doi: 10.3390/ijms241210140. Int J Mol Sci. 2023. PMID: 37373286 Free PMC article.
Circadian genes are a set of genes that regulate the body's internal clock and influence various physiological processes, including sleep-wake cycles, metabolism and immune function. ...The strongest correlation was found for neutrophils and was followed by circadian genes …
Circadian genes are a set of genes that regulate the body's internal clock and influence various physiological processes, including s …
DEC1/STRA13/SHARP2 and DEC2/SHARP1 coordinate physiological processes, including circadian rhythms in response to environmental stimuli.
Kato Y, Kawamoto T, Fujimoto K, Noshiro M. Kato Y, et al. Curr Top Dev Biol. 2014;110:339-72. doi: 10.1016/B978-0-12-405943-6.00010-5. Curr Top Dev Biol. 2014. PMID: 25248482 Review.
Daily physiological and behavioral rhythms are regulated by endogenous circadian molecular clocks. Clock proteins DEC1 (BHLHe40) and DEC2 (BHLHe41) belong to the basic helix-loop-helix protein superfamily, which contains other clock proteins CLOCK …
Daily physiological and behavioral rhythms are regulated by endogenous circadian molecular clocks. Clock proteins DEC1 (BHLHe4 …
Genetic Markers of Differential Vulnerability to Sleep Loss in Adults.
Casale CE, Goel N. Casale CE, et al. Genes (Basel). 2021 Aug 26;12(9):1317. doi: 10.3390/genes12091317. Genes (Basel). 2021. PMID: 34573301 Free PMC article. Review.
Specifically, we discuss polymorphisms in adenosinergic genes (ADA and ADORA2A), core circadian clock genes (BHLHE41/DEC2 and PER3), genes related to cognitive development and functioning (BDNF and COMT), dopaminergic genes (DRD2 and DAT), and immune and clearance g …
Specifically, we discuss polymorphisms in adenosinergic genes (ADA and ADORA2A), core circadian clock genes (BHLHE41/DEC2 and …
Dec1 and Dec2 are regulators of the mammalian molecular clock.
Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y, Honma K. Honma S, et al. Nature. 2002 Oct 24;419(6909):841-4. doi: 10.1038/nature01123. Nature. 2002. PMID: 12397359
The proteins Clock and Bmal1 form a heterodimer which activates the transcription of the Per gene from the E-box elements in its promoter region. ...A brief light pulse induced Dec1 but not Dec2 expression in the suprachiasmic nucleus in a phase-dependent manner. Dec1 and …
The proteins Clock and Bmal1 form a heterodimer which activates the transcription of the Per gene from the E-box elements in its prom …
35 results